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http://pr.cannazine.co.uk : Lipitor has proven a hugely effective medicine for lowering high LDL cholesterol—the main target of cholesterol-lowering therapy. It offers fast results which can be measurable in only two weeks.
Lipitor is also the most heavily prescribed drug in history with sales of $12 billion dollars world wide in 2008. $7 billion worth of those sales alone in the United States.
Lipitor is a veritable super-drug responsible for saving tens of thousands of lives every single year.
But how does it work? What makes Lipitor the No#1 cholesterol lowering drug on the market today?
Lipitor Lipitor works by blocking an enzyme in the liver that your body uses to make cholesterol.
When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream. This results in lower levels of cholesterol circulating in your blood, which is good news all round.
But without any treatment and a high colesterol diet, all that cholesterol builds up in the blood stream and is transported around the body, through the heart valves etc.
A condition which can ultimately lead to heart disease.
In techo-speak, Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol.
Cholesterol and triglycerides circulate in the bloodstream as part of lipoprotein complexes.
With ultracentrifugation, these complexes separate into HDL (high-density lipoprotein), IDL (intermediate-density lipoprotein), LDL (low-density lipoprotein),and VLDL (very-low-density lipoprotein) fractions. Triglycerides (TG) and cholesterol in the liver are incorporated into VLDL and released into the plasma for delivery to peripheral tissues.
LDL is formed from VLDL and is catabolized primarily through the high-affinity LDL receptor.
Clinical and pathologic studies show that elevated plasma levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipoprotein B (apo B) promote human atherosclerosis and are risk factors for developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk.
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